Dr. Mathumathi Rajavel

Title: 
Associate Professor of Medical Technology
Office Location: 
Spencer Hall 106 - Lab: Dixon 218D & 225
Phone: 
(443) 885-1553
Email: 
Mathumathi.Rajavel@morgan.edu
Education:

Postdoctoral: Johns Hopkins University Bloomberg School of Public Health
Temple University School of Medicine
Ph.D. Molecular Biology, Madurai Kamarai University
M.Sc. Microbiology, Madurai Kamaraj University

Education:

Postdoctoral: Johns Hopkins University Bloomberg School of Public Health
Temple University School of Medicine
Ph.D. Molecular Biology, Madurai Kamarai University
M.Sc. Microbiology, Madurai Kamaraj University

Research Interests:

Molecular Microbiology. Research in my laboratory focuses on manipulating bacteriophages to combat infections caused by bacterial pathogens, more specifically, we explore the utility of phages in various applications: alternate to antibiotic treatment, bacterial/bioagent detection, environmental bacterial decontamination as well as novel vaccine delivery vehicles. We investigate these projects using microbiological, genomic, biochemical and molecular biological approaches.

Selected Publications:

  • Gary Xie , Shannon L. Johnson, Karen W. Davenport , Mathumathi Rajavel, Torsten Waldminghaus, John C. Detter , Patrick S. Chain , Shanmuga Sozhamannan (2017). "Exception to the Rule: Genomic Characterization of Naturally Occurring Unusual Vibrio cholerae Strains with a Single Chromosome," International Journal of Genomics, vol. 2017, Article ID 8724304, 14 pages, 2017. doi:10.1155/2017/8724304.
  • Fouts DE, Klumpp J, Bishop-Lilly KA, Rajavel M, Willner KM, Butani A, Henry M, Biswas B, Li M, Albert MJ, Loessner MJ, Calendar R, Sozhamannan S. (2013). Whole genome sequencing and comparative genomic analyses of two Vibrio cholerae O139 Bengal-specific Podoviruses to other N4-like phages reveal extensive genetic diversity. Virol J. 28: 10: 165.
  • Shanmuga Sozhamannan, Kimberly Bishop-Lilly and Mathumathi Rajavel. (2010). Whole-genome Sequencing (WGS) and the Changing Landscape of Bacterial Genetics. ASM Microbe 5: 41-42.
  • Mathumathi Rajavel, Bevin Philip, Benjamin M. Buehrer, Beverly Errede and David Levin (1999). Mid2 is a Putative Sensor for Cell Integrity Signaling in Saccharomyces cerevisiae. Molecular and Cellular Biology 19: 3969-3976.
  • Jeffrey Gross, Mathumathi Rajavel and Charles Grubmeyer (1998). Kinetic Mechanism of Nicotinic Acid Phosphoribosyltransferase: Implications for Energy Coupling. Biochemistry 37: 4189-4199.
  • Mathumathi Rajavel, Jeffrey Gross and Charles Grubmeyer (1998). Conversion of an Allosteric Stimulator to an Inhibitor: Phosphorylation Mutants of Nicotinic Acid Phosphoribosyltransferase. Biochemistry 37: 4181-4188.
  • Jeffrey Gross, Mathumathi Rajavel, Edy Segura and Charles Grubmeyer (1996). Energy Coupling in Salmonella Typhimurium Nicotinate Phosphoribosyltransferase: Identification of His-219 as site of Phosphorylation. Biochemistry 35: 3917-3924.
  • Mathumathi Rajavel, Jeffrey Gross, Edy Segura, William Moore and Charles Grubmeyer (1996). Limited Proteolysis of Salmonella Typhimurium Nicotinate Phosphoribosyltransferase reveals ATP-Linked conformational change. Biochemistry 35: 3909-3916.
  • T. Seetha Ratnakumari, R. Mathumathi and K. Dharmalingam (1994). DNA amplification affects protease production and sporulation in Streptomyces fradiae. Current Microbiology 29: 101-107.
  • R. Mathumathi, S. Kumaravel and K. Dharmalingam (1990). Deamplification and Deletion of Amplified DNA in S. lividans And S. fradiae. Applied Microbiology and Biotechnology 33: 291-295.

Book Chapter:

Charles Grubmeyer, Jeffrey Gross and Mathumathi Rajavel (1999). Energy Coupling in Nicotinate Phosphoribosyltransferase. Methods in Enzymology 308: 28-48.