Dr. Gloria Hoffman

Title: 
Professor of Biology
Office Location: 
Dixon Research Center 221/222
Phone: 
(443) 885-3394 (office); (443) 885-4448 (laboratory)
Email: 
Gloria.Hoffman@morgan.edu
Education:

Postdoctoral Fellow, University of Rochester, Anatomy, 1974-1978
Ph.D., University of Illinois, School of Medicine, Chicago, Pharmacology, 1974
B.S., University of Illinois, Chicago, Biology, 1968

Education:

Postdoctoral Fellow, University of Rochester, Anatomy, 1974-1978
Ph.D., University of Illinois, School of Medicine, Chicago, Pharmacology, 1974
B.S., University of Illinois, Chicago, Biology, 1968

Research Interests:

  • Systems neuroscience
  • Neuroendocrinology
  • Neuronal plasticity
  • Genetics of neurological diseases
  • Brain effects of sleep disorders

Current Research:

My laboratory investigates the regulation of reproductive cycles, lactation, and parturition, water balance and food intake, and processing of stressful stimuli. Studies address how brain circuits controlling food intake and metabolism change after of chronic sleep disruption and how sleep problems disrupt memory and learning. Additional projects focus on the Fragile X gene: premutations (carried by about 1 in 200 women) that produces motor problems in men and reproductive problems in women, and full mutations that lead to autism. A separate direction is how ovarian hormones affect the injured brain. My laboratory studies seizures and head trauma, and mutations in a gene that affects mitochondria which leads to Parkinson's disease.

All studies have a common feature: functional anatomy to understand normal and pathological processes. I have devised widely-used techniques for localizing specific proteins, mRNA, and other molecules in brain. I also run workshops for the International Brain Research Organization, Histochemical Society, and Society for Neuroscience.

Selected Publications (citations, 13,135; h-index, 61; h10-index, 158):

  • Conca Dioguardi, C., Uslu, B., Haynes, M., Kurus, M., Gul, M., Miao, D-Q, De Santis, L., Ferrari, M., Bellone, S., Santin, A., Giulivi, C., Hoffman, G.E., Usdin, K., and Johnson, J. (2016). Oocyte and granulosa cell mitochondrial abnormalities in a mouse model of Fragile X primary ovarian insufficiency. Molecular Human Reproduction, 22(6):384-96. doi: 10.1093/molehr/gaw023; PMID: 26965313.
  • Hoffman, G.E., Murphy, K.J., and Sita, L.V. (2016). Importance of titrating antibodies. Current Protocols in Neuroscience, 76: 2.12, 12.1-12.37. doi: 10.1002/cpns.1; PMID: 27367962.
  • Novairo, H.J., Graceli, J.B., Capellino, S., Schoeffield, A., Hoffman, G.E., Wolfe, A., Wondisford, F. and Radovick, S. (2016). Development and characterization of novel rat anti-mERβ sera. Endocrinology, 157(7):2844-52. doi: 10.1210/en.2016-1122; PMID: 27105387.
  • Hoffman, G.E. and Koban, M. (2016). Staying Awake: Chronic sleep deprivation of rats up-regulates hypothalamic l-histidine decarboxylase. PLoS ONE, Dec 20;11(12):e0152252. PMID: 27997552; doi: 10.1371/journal.pone.0152252.
  • Novaira, H.J., Sonko, M.L., Hoffman, G.E., Koo, Y., Ko, C., Wolfe, A. and Radovick, S. (2014). Disrupted kisspeptin signaling in GnRH neurons leads to reproductive abnormalities associated with hypogonadotrophic hypogonadism. Molecular Endocrinology, 28(2):225-38. doi: 10.1210/me.2013-1319; PMID: 24422632.
  • Ivell, R., Teerds, K., and Hoffman, G.E. (2014). Proper application of antibodies for immunohistochemical detection: antibody crimes and how to prevent them. Endocrinology, 155(3):676-87. doi: 10.1210/en.2013-1971; PMID: 24428532.
  • Hermanstyne, T.O., Subedi, K., Le, W.W., Hoffman, G.E., Meredith, A.L., Mong, J.A., and Misonou, H. (2013). Kv2.2: a novel molecular target to study the role of basal forebrain GABAergic neurons in the sleep-wake cycle. Sleep, 36(12):1839-48. doi: 10.5665/sleep.3212; PMID: 24293758.