Yongchao   Zhang

Associate Professor


Ph.D. Chemistry, University of Texas at Austin


Development of biological and environmental sensors, synthesis and modifications of bio-polymers and bio/nano composite materials and their applications in biosensors and biofuel cells.


1.  Deng, D.; Zhang, Y. Two-pulse systems and methods for determining analyte concentration. US Patent Application 20090026094, January, 2009. 

2.  Heller, A.; Zhang, Y.; etc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods. US Patent 7,368,190, May 2008.


Zhang, Y.; Ji, C. Electro-Induced Covalent Cross-Linking of Chitosan and Formation of Chitosan Hydrogel Films: Its Application as an Enzyme Immobilization Matrix for Use in a Phenol Sensor. Anal. Chem. 2010, in press.

 Zhang, Y.; Heller, A. Reduction of the Nonspecific Binding of a Target Antibody and of Its Enzyme-Labeled Detection Probe Enabling Electrochemical Immunoassay of an Antibody through the 7 pg/mL-100 ng/mL (40 fM-400 pM) Range. Anal. Chem. 2005, 77, 7758-7762.

Kang, C.; Shin, H.; Zhang, Y.; Heller, A. Deactivation of Bilirubin Oxidase by a Product of the Reaction of Urate and O2. Bioelectrochemistry 2004, 65, 83-88.

Zhang, Y.; Pothukuchy, A.; Shin, W.; Kim, Y.; Heller, A. Detection of ~ 103 Copies of DNA by an Electrochemical Enzyme-Amplified Sandwich-Assay with Ambient O2 as the Substrate. Anal. Chem. 2004, 76, 4093-4097.

Kim, H.-H.; Zhang, Y.; Heller, A. Bilirubin Oxidase-Label for an Enzyme-Linked Affinity Assay with O2 as Substrate in a Neutral pH NaCl Solution. Anal. Chem. 2004, 76, 2411-2414.

Zhang, Y.; Kim, H.-H.; Heller, A.  Enzyme-Amplified Amperometric Detection of 3000 Copies of DNA in a 10-µL Droplet at 0.5 fM Concentration.  Anal. Chem. 2003, 75, 3267-3269.

Kim, H.-H.; Mano, N.; Zhang, Y.; Heller, A.  A Miniature Membrane-less Biofuel Cell Operating under Physiological Conditions at 0.5 V.  J. Electrochem. Soc. 2003, 150, A209-A213.

Zhang, Y.; Kim, H.-H.; Mano, N.; Dequaire, M.; Heller, A.  Simple Enzyme-Amplified Amperometric Detection of a 38-Base Oligonucleotide at 20 pM Concentration in a 30µL Droplet.   Anal. Bioanal. Chem. 2002, 374, 1050-1055.

Mano, N.; Kim, H.-H.; Zhang, Y.; Heller, A.  An Oxygen Cathode Operating in a Physiological Solution.  J. Am. Chem. Soc. 2002, 124, 6480-6486.

Gao, Z.; Binyamin, G.; Kim, H.-H.; Barton, S.C.; Zhang, Y.; Heller, A.  Electrodeposition of Redox Polymers and Co-Electrodeposition of Enzymes by Coordinative Crosslinking.  Angew. Chem. 2002, 41, 810-813.

Barton, S.C.; Kim, H.-H.; Binyamin, G.; Zhang, Y.; Heller, A.  Electroreduction of O2 to Water on the "Wired" Laccase Cathode.  J. Phys. Chem. B 2001, 105, 11917-11921.

Chen, T.; Barton, S.C.; Binyamin, G.; Gao, Z.; Zhang, Y.; Kim, H. -H.; Heller, A.  A Miniature Biofuel Cell.  J. Am. Chem. Soc. 2001,123, 8630-8631.

Barton, S.C.; Kim, H.-H.; Binyamin, G.; Zhang, Y.; Heller, A.  The "Wired" Laccase Cathode: High Current Density Electroreduction of O2 to Water at +0.7 V (NHE) at pH 5.  J. Am. Chem. Soc. 2001, 123, 5802-5803.