Yun-Chi  Chen

Associate Professor

 

Laboratory of Immunology and Infectious Diseases      
PI: Dr. Yun-Chi Chen

Research Interests and Summary

My research group has been actively involved in a variety of research projects. These are chiefly related to immunology, virology, microbiology, molecular and cellular biology as well as vaccinology, epidemiology and preventive medicine. We have strong interests and willpower to integrate these subjects to make a difference. Specifically, we have been studying host cell and immune responses to various infections or immunizations, including dengue virus, West Nile virus, vaccinia virus (the smallpox vaccine), influenza vaccine, and malaria parasites, regarding the functions and differentiation of different types of immune cells, such as monocytes, macrophages, dendritic cells and B and T lymphocytes, in humans and animal models. As such, the research that we are developing at Morgan will be multidisciplinary which cuts across basic, translational and epidemiological studies. They can be summarized as following:

  1. Molecular and cellular aspects of immune cell functions and differentiation;
  2. Innate and adaptive immune responses to infections and vaccinations in humans and animal models;
  3. Viral immunity and pathogenesis; virus-host interactions;
  4. Rational design and evaluation of novel vaccine regimens and strategies;
  5. Immunological factors involved in individual variability and ethnic health disparities regarding host susceptibility and responses to infections and immunizations.

Lab Specialty and Expertise

Immunology

Virology/Parasitology/Microbiology

Infectious Diseases

Molecular and Cell Biology

Vaccine Research and Development

Epidemiology/Preventive Medicine/Global Health

Biotechnology

Clinical/Translational Research

 

Key words

1. Pathogens: Dengue, Vaccinia, Smallpox, Influenza, Hepatitis C, West Nile, HIV, Malaria

2. Immunology: Molecular and Cellular, Microbial, Vaccine, Antiviral

3. Immunology: Innate immunity, Antibody response, Immunological memory, T cells, Lymphocyte differentiation, Monocytes/Macrophages, Dendritic cells, Host defense, Organ-specific immunity, Cytokines/Chemokines, Multiparameter flow cytometry, microRNA, TCR signaling, Immunotherapy

4. Vaccinology: Immune response, Vaccine construct, Vaccine adjuvant, Recombinant DNA, Human vaccination, Immunological evaluation, Translational research

5. Epidemiology: Epidemiology of infectious diseases, Emerging infectious diseases, Pathogenesis of infectious diseases, Molecular epidemiology, Hospital infection, Outbreak, Surveillance, Field, Community, Pathogen detection/isolation

CHEN GROUP MEMBERS

Contact: Yun-Chi CHEN, Ph.D. (D.Phil. Oxon)
Associate Professor
Department of Biology
School of Computer, Mathematical, and Natural Sciences
Morgan State University
1700 East Cold Spring Lane,
Baltimore MD 21251
Office: 212 Richard N. Dixon Research Building
Laboratory: 211 Richard N. Dixon Research Building
Phone: 443-885-1997
Fax: 443-885-8285