Kadir Aslan

Title: 
Assistant Dean for Research and Graduate Studies and Professor
Office Location: 
Dixon Research Center, Room 124
Phone: 
443-885-4257
Email: 
Kadir.Aslan@morgan.edu
Website: 
http://www.morgan.edu/kadiraslan
Education:

Ph.D. in Chemical Engineering, Illinois Institute of Technology, 2003.
M.Sc. in Chemical Engineering, Middle East Technical University (Turkey), 1998.
B.Sc. in Chemical Engineering, Hacettepe University (Turkey), 1995.

Education:

Ph.D. in Chemical Engineering, Illinois Institute of Technology, 2003.
M.Sc. in Chemical Engineering, Middle East Technical University (Turkey), 1998.
B.Sc. in Chemical Engineering, Hacettepe University (Turkey), 1995.

ASLAN RESEARCH GROUP MEMBERS

ASLAN RESEARCH GROUP NEWS

RESEARCH CAPABILITIES

PUBLICATIONS

GOOGLE SCHOLAR PAGE (6053 citations, h-index: 40)

RESEARCHGATE PROFILE

FULL CV (11/30/2015)

 

CURRENT AND PREVIOUS FUNDING (Total: $1,863,136):

  1. The Naval Surface Warfare Center, Naval Engineering Education Consortium (NEEC) (March 2016 - February 2019): $450,000
  2. JHU-CMEDE, Polymers/Composites Group (May 2015 - December 2016): $212,600
  3. NIH, STTR Phase 1 Subaward (April 2015 - March 2017): $89,843
  4. Morgan ASCEND Instrumentation Grant - SEM (April 2016): $85,600
  5. Morgan ASCEND Instrumentation Grant - UV/Vis (April 2015): $14,456
  6. Morgan ASCEND Instrumentation Grant - Microwave System (April 2015): $17,000
  7. The Naval Surface Warfare Center,  Technology Evaluation (October 2014- September 2015): $140,000
  8. TEDCO, Maryland Innovation Initiative, Phase 2 Award (September 2014-December 2014): $15,000
  9. TEDCO, Maryland Innovation Initiative, Phase 1 Award (March 2013-December 2013): $100,000
  10. National Institutes of Health, K25 Career Development Award (2008-2013): $606,637
  11. American Heart Association, Beginning-in-Aid Grant (2007-2009): $132,000
  12. American Chemical Society, PROJECT SEED Award (Summer 2012): $5,000 (returned)

RESEARCH INTERESTS:

Nanotechnology: Plasmonics, Metal-Enhanced Fluorescence, Metallic Nanoparticles, Ultra Fast Surface Chemistry, Ultra Fast Nanoparticle-Based Assays, Metal-Assisted Crystallization.
Biotechnology: Medical biotechnology, Biosensors, Plasmon-Enhanced Enzymatic Reactions, Biological Hydrogen Production..




RESEARCH PROJECTS:
1. Plasmonics: Metal-Enhanced Fluoresecence based Biosensing
My research focuses on the development and applications of plasmonic / fluorescence-based biosensors using noble metallic nanoparticles. In this regard, we have developed a new approach to glucose sensing based on the reversible aggregation of gold nanoparticles (due to specific dextran / Concanavalin A / glucose interactions) and their respective change in plasmon absorption (and scattering) upon glucose addition. This method proves to offer an across-the-board technology for glucose sensing in different physiological fluids due to its tunable glucose sensing range, where glucose can vary significantly from tears to blood, and its optical compatibility (absorbance above 600 nm). 

We have shown that a fluorescence-based detection scheme for small molecules can be realized using ligand-functionalized gold nanoparticles. The transduction scheme is based on the strong quenching of the fluorescence emission exerted by metallic surfaces on fluorophores positioned in their immediate vicinity (< 10 nm). In this regard, we have employed biotin (as a model small molecule) and its fluorophore-labeled antibody.

Metal Nanostructures

We reported the first findings of MEF from modified plastic substrates. We have showed how plastic surfaces can be modified to obtain surface functionality, which in turn allows for silver deposition and therefore MEF of fluorophores positioned above the silver using a protein spacer. Our findings show that plastic substrates are ideal surfaces for metal-enhanced phenomena, producing similar enhancements as compared to clean glass surfaces. We speculate that plastic substrates for MEF will find common place, as compared to the more expensive and less versatile traditional silica based supports.

MEF from plastics
2. Metal-Assisted and Microwave-Accelerated Evaporative Crystallization
Aslan Research Group has reported a platform technology, called Metal-assisted and microwave-assisted evaporative crystallization (MA-MAEC), which is based on the combined use of silver nanoparticles and microwave heating for selective and rapid crystallization of small molecules. In this regard, the crystallization of a model small molecule (glycine) was achieved in several seconds. Glycine crystals grown on silver nanostructures with and without microwave heating were found to be larger than those grown on blank glass slides. The MA-MAEC technique has the potential to selectively grow the desired polymorphs of small molecules “on-demand” in a fraction of the time as compared to the conventional evaporative crystallization.

3. Alternative Treatment of Gout using Nanoparticles and Medical Microwaves
My research group recently presented a platform technology, called Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD), which is based on the use of dispersion of gold colloids with low power microwave heating to decrystallize organic and biological crystals attached to surfaces. Uric acid crystals were chosen as model target crystals to be decrystallized using MAMAD technique. A two-step procedure was employed: 1) growth of uric acid crystals on a model surface (collagen films coated on to glass slides to simulate a human joint) at room temperature and 2) de-crystallization of uric acid crystals in synovial fluid (in vitro) using silver and gold colloids in conjunction with low power microwave heating. Using the MAMAD technique with gold colloids, the number of uric acid crystals was drastically reduced by 80% after 10 min, where the average size of the uric acid crystals was reduced from 125 μm to 50 μm. In control experiments and with silver colloids that aggregated from the solution, the size and number of uric crystals remained unchanged, indicating that the combined use of only metal colloids in solution and microwave heating is effective for the de-crystallization of uric acid crystals in biological media.

3. Plasmon-Enhanced Enzymatic Reactions
Aslan Research Group presented a detailed investigation of the dependence of enzymatic activity on the nanoparticle-enzyme distance and nanoparticle loading on planar surfaces. In this regard, three different SIFs were prepared (low, medium and high loading) on APTS-coated glass slides. The loading of SIFs on glass slides were monitored by the absorbance of surface plasmon resonance peak of silver. These silvered surfaces and unsilvered (blank) APTS-coated glass slides (control experiment) were used for the comparison of three different enzyme immobilization strategies for plasmon-enhanced enzymatic activity. A biotin-avidin protein assay (strategy 1), SAMs (strategy 2) and poly-l-lysine layer (strategy 3) were used to vary the distance of the enzyme from the silver surface. The enzymatic activity was followed by the colorimetric measurement of the product produced as a result of enzymatic conversion of o-phenylenediamine (OPD) on silvered surfaces and blank glass slides. It was found that up to an %200 increase in enzymatic conversion of OPD was observed from SIFs with high using strategy 1, providing direct evidence that plasmon-enhanced enzymatic activity is highly dependent on the enzyme-nanoparticle distance and the extent of loading of silver nanoparticles. These findings will help the scientific community to better design enzyme-nanoparticle hybrid systems for applications in bionanotechnology.

4. Characterization of Composite Materials
The objective of this project is to help the development of damage metrics for samples of S2 glass/epoxy when such samples are exposed to ballistic impact by Composites CMRG. We propose to determine the morphology of the damage created by a projectile at various speeds based on optical photography and optical and electron microscopy. MSU students and the PI will carry out portions of the work at the facilities of the Composites CMRG's partner institutions (ARL, JHU and University of Delaware).

5. Development of Lithium Ion Batteries using a Novel Electrode (coming soon)

6. Development of Anti-Cancer Agents (Coming soon)

AWARDS, SCHOLARSHIPS AND PROFESSIONAL SOCIETY MEMBERSHIPS
1998 - 1999 NATO and TUBITAK (The Scientific and Technical Research Council of Turkey) PhD Program Grant in Chemical Engineering (Illinois Institute of Technology)
2001 - Present Member of the American Chemical Society (ACS)
2004 - 2006 Member of the Biophysical Society
2004 - 2006 Member of the International Society for Optical Engineering (SPIE)
1998 - 2003 Member of the American Institute of Chemical Engineers (AIChE).

PUBLICATIONS: Out of >120:
1. Aslan, K.; Pérez-Luna, V.H. "Surface Modification of Colloidal Gold by Chemisorption of Alkanethiols in the Presence of a Nonionic Surfactant", Langmuir (2002), 18, 6059-6065.
2. Aslan, K.; Pérez-Luna, V.H. "Nonradiative Interactions between Biotin Functionalized Gold Nanoparticles and Fluorophore-Labeled Antibiotin" Plasmonics (2006), 1 (2-4), 111-119.
3. Aslan, K. "Rapid Whole Blood Bioassays using Microwave-Accelerated Metal-Enhanced Fluorescence", Nano Biomedicine and Engineering (2010), 2 (1), 1-9.
4. Addae, S.; Pinard, M.; Caglayan, H.; Cakmakyapan, S.; Caliskan, D.; Ozbay, E.; Aslan*, K. "Rapid and Sensitive Colorimetric ELISA using Silver Nanoparticles, Microwaves and Split Ring Resonator Structures", Nano Biomedicine and Engineering, (2010), 2 (3), 155-164.
5. Caglayan, H.; Cakmakyapan, S.; Addae, S.; Pinard, M.; Caliskan, D.; Aslan, K.; Ozbay, E. "Ultrafast and Sensitive Bioassay using Split Ring Resonator Structures and Microwave Heating" Applied Physics Letters, (2010), 97 (9), 093701.
6. Pinard, M.; and Aslan, K. "Metal-Assisted and Microwave-Accelerated Evaporative Crystallization", Crystal Growth and Design", (2010), 10 (11), 4706-4709.
7. Grell, T.A.J.; Ortiz, E. P.; Das, S.R.; and Aslan*, K. "Quantitative Comparison of Protein Surface Coverage on Glass Slides and Silver Island Films in Metal-Enhanced Fluorescence-based Biosensing Applications", Nano Biomedicine and Engineering, (2010), 2 (3), 165-170.
8. Alabanza, M.; Anginelle; Aslan*, K. "Metal-Assisted and Microwave-Accelerated Evaporative Crystallization: Application to L-Alanine", Crystal Growth and Design", (2011), 11(10), 4300-4304
9. Alabanza, M. A.; Pozharski, E.; Aslan*, K. "Rapid Crystallization of L-Alanine on Engineered Surfaces using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization", Crystal Growth and Design, (2012), 12(1), 346-353.
10. Mohammed, M,; Syed, M.F.; Aslan*, K., "Microwave-Accelerated Bioassay Technique for Rapid and Quantitative Detection of Biological and Environmental Samples", Biosensors and Biolectronics, (2016), 75, 420-426 

PATENTS:
1.  Aslan, K. " Decrystallization of Uric Acid Crystals", US 62/386,153
2. Aslan, K., "Metal-Assisted and Microwave-Accelerated Evaporative Crystallization", US Patent No: 9,243,017 (January 26, 2016), CA2851361A1, WO2013055859A1.
3. Geddes, C.D.; Aslan, K.,"Metal-Enhanced Fluorescence from Plastic Substrates", World Intellectual Property Organization: WO2006052548; US Patent  No. 8075956.
4. Geddes, C.D.; Aslan, K., "Microwave-Accelerated Plasmonics" US Patent No. 20120107952.

PEER-REVIEW:

Grant Proposal: American Chemical Society, Petroleum Research Fund (2008), NSF HBCU-UP (2012-cont'd), FCT Portugal (2012-Cont'd).

Manuscript Referee: Clinical Chemistry (2005-continued), Langmuir (2005-continued), Canadian Journal of Biosystems Engineering (2007-continued), Biotechnology Progress (2007-continued), Analytical Biochemistry (2007-continued), Applied Physics Letters (2008-continued), Nucleic Acids Research (2008-continued), Analytical Chemistry (2008-continued), The Journal of Physical Chemistry (2008-continued), International Journal of Environmental Analytical Chemistry (2008-continued), Modern Physics Letters B (2008-continued), Journal of Biomedical Optics (2008-continued), Applied Surface Science (2010-continued).

COURSES TAUGHT:
Chem 101: General Chemistry - Laboratory
Chem 105: General Chemistry - Lecture / Laboratory
Chem 314: Instrumental Analysis - Lecture / Laboratory
Chem 407, Advanced Topics in Physical Chemistry - Lecture
Chem 581: Advanced Techniques in Chemistry - Lecture / Laboratory
Chem 603, Thermodynamics - Lecture